A leading biopharmaceutical company is seeking an experienced Scientist to join their Antibody Cell Line Sciences team. This group sits within the Antibody and Novel Therapeutics function and plays a key role in developing engineered mammalian cell lines that support the manufacture of innovative therapeutic antibodies and complex biologics.
This is a hands-on laboratory role focused on host cell line development, cell line engineering, and optimisation of stable mammalian expression systems for antibody production.
Key Responsibilities
*Establish and develop a toolbox of host cell lines suitable for manufacturing, applying strong laboratory-based scientific expertise
*Ensure host systems can express a diverse range of molecule types and meet GMP manufacturing requirements, supported by robust documentation
*Engineer and generate stable mammalian cell lines for antibody and novel antibody-format expression
*Apply a variety of host engineering and genome editing techniques to develop improved expression systems
*Analyse expression and engineering data to draw clear conclusions and inform next steps
*Work closely with molecular biology and engineering teams to drive technical progress
*Communicate progress effectively across multidisciplinary teams, highlighting risks, issues, and potential opportunities
*Maintain accurate documentation and records in line with scientific and regulatory standards
Skills & Experience
*Minimum BSc in a relevant life sciences discipline
*Experience generating stable mammalian cell lines for protein or antibody expression
*Strong cell culture expertise, ideally within a biopharmaceutical environment
*Experience with genome engineering technologies, such as CRISPR-based cell engineering
*Competence in key molecular biology techniques, including ddPCR, cloning, and plasmid construction
*Hands-on experience with flow cytometry / FACS and single-cell cloning systems
The role is offered on an initial 12 month contract with realistic potential for extension.
This is an excellent opportunity to join a collaborative scientific team contributing directly to the development and manufacture of next-generation biologics.
VRS9388SE